PMID

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Article Title

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Potent and selective ET-A antagonists. 2. Discovery and evaluation of potent and water soluble N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives.

Tanabe Seiyaku

Synthesis and structure-activity relationships of 2-substituted D-tryptophan-containing peptidic endothelin receptor antagonists: importance of the C-2 substituent of the D-tryptophan residue for endothelin A and B receptor subtype selectivity.

Tsukuba Research Institute

Endothelin-1 analogues substituted at both position 18 and 19: highly potent endothelin antagonists with no selectivity for either receptor subtype ETA or ETB.

Takeda Chemical Industries

Endothelin: a new challenge.

Warner-Lambert

 

IRL 2500: A potent ETB selective endothelin antagonist

TBA

 

A case study of combinatorial libraries: Endothelin receptor antagonist hexapeptides

TBA

 

Synthesis of 2-substituted d-tryptophan-containing peptide derivatives with endothelin receptor antagonist activity

TBA

Development and evaluation of endothelin-A receptor (radio)ligands for positron emission tomography.

University Hospital Mu£Nster

PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studies.

University Hospital M£Nster

Isolation and Structure Elucidation of 34-Sulfatobastadin 13, an Inhibitor of the Endothelin A Receptor, from a Marine Sponge of the Genus Ianthella

TBA

 

RES-701-1/endothelin-1 hybrid peptide having a potent binding activity for type B receptor

TBA

 

Analogs of an endothelin antagonist RES-701-1: substitutions of C-terminal amino acid

TBA

 

Linear peptide ET_A antagonists: rational design and practical derivatization of N-terminal amino- and imino-carbonylated tripeptide derivatives

TBA

 

Endothelin eceptor Ligands. Multiple D-Amino acid replacement net approach

TBA

 

Endothelin receptor ligands. replacement net approach to SAR determination of potent hexapeptides

TBA

 

CGS 27830, a potent nonpeptide endothelin receptor antagonist

TBA

Modifications and structure-activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists.

Tanabe Seiyaku

Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives.

Tanabe Seiyaku

Peptoids as endothelin receptor antagonists.

Ranbaxy Laboratories

Semisynthetic studies identify mitochondria poisons from botanical dietary supplements--geranyloxycoumarins from Aegle marmelos.

University of Mississippi

Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists.

Tsukuba Research Institute